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GSK1362

CAT: 0013-GTR19272894-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272894-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK1362 is a selective inverse agonist of REV-ERB. It disrupts the interaction between REV-ERBα and corepressors (NCoR1, SMRT2, RIP140) . By enhancing the transcription of BMAL1, GSK1362 acts as an inverse agonist, counteracting endogenous REV-ERB ligands that inhibit BMAL1. GSK1362 suppresses the expression of inflammation factors induced by LPS and inhibits IL-1β-induced Cxcl5 transcription in cells. It is utilized in the study of inflammatory diseases.
CAS Number
2986733-57-5
Smiles
N#CC=1N=C (OC1NCCOC) C=2C=CC (=CC2) N (C) CC3=CC=C (Cl) C=C3
Molecular Formula
C21H21ClN4O2
Molecular Weight
396.88
Storage Conditions
-20°C
Notes
For research use only.

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