Products for Research Use Only

Opitor-0

CAT: 0013-GTR19272837-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19272837-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Opitor-0 is a highly selective OPA1 GTPase inhibitor with an IC50 of 3 μM. Opitor-0 disrupts the stability of OPA1 oligomers, triggering mitochondrial cristae remodeling and fragmentation, which leads to massive release of cytochrome c and subsequently induces apoptosis. In anticancer studies, Opitor-0 has been shown to exhibit synergistic effects when combined with the Bcl-2 inhibitor ABT-737 or Venetoclax.
Purity
98.61% (May vary between batches)
Smiles
CC1=NN (C2=C1C=C (C (NC3=C (C) N (CC4=CC=CC=C4) N (C5=CC=CC=C5) C3=O) =O) S2) C6=CC=CC=C6
Molecular Formula
C30H25N5O2S
Molecular Weight
519.62
Storage Conditions
-20°C
Notes
For research use only.