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PDE4B-IN-6

CAT: 0013-GTR19272714-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272714-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4B-IN-6 (Compound 4i) is a potent and highly selective inhibitor of phosphodiesterase 4B (PDE4B) with an IC50 of 7.42 nM. As a roflumilast analogue, it exhibits significantly higher selectivity for PDE4B over PDE4A (IC50 = 1540 nM, ~195-fold) and PDE4C (IC50 = 1260 nM, ~169-fold) . PDE4B-IN-6 exerts anti-inflammatory effects by elevating intracellular cAMP levels and suppressing the expression of the pro-inflammatory cytokine TNF-α. Additionally, it demonstrates good antioxidant properties and low cytotoxicity, making it suitable for research on chronic obstructive pulmonary disease (COPD) and related inflammatory conditions.
Purity
99.20% (May vary between batches)
Smiles
FC (F) OC1=CC=C (C (NNC (C2=CC (OC) =C (OC) C (OC) =C2) =O) =O) C=C1OCC3CC3
Molecular Formula
C22H24F2N2O7
Molecular Weight
466.43
Storage Conditions
-20°C
Notes
For research use only.

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