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Creosol

CAT: 0804-HY-W040971-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W040971-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable[1][2][3].
CAS Number
93-51-6
Product Name Alternative
2-Methoxy-4-methylphenol
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Akt; Endogenous Metabolite; ERK; FAK; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/creosol.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C)C=C1OC
Molecular Formula
C8H10O2
Molecular Weight
138.17
Precautions
H302, H315, H319
References & Citations
[1]Yin J, et al. Purification of creosol applying green heterogeneous extraction technology[J]. Journal of Chemical Technology & Biotechnology, 2022, 97 (10) : 2945-2951.|[2]Meylemans HA, Groshens TJ, Harvey BG. Synthesis of renewable bisphenols from creosol. ChemSusChem. 2012 Jan 9;5 (1) :206-10. |[3]Aliu E, et al. Mild-Temperature hydrodeoxygenation of vanillin a typical bio-oil model compound to Creosol a potential future biofuel[J]. Catalysis Today, 2021, 379: 70-79.|[4]Lee JH, et al., Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. Mar Drugs. 2018 Apr 6;16 (4) :121.|[5]Tevzadze G, et al. Gut neurotoxin p-cresol induces brain-derived neurotrophic factor secretion and increases the expression of neurofilament subunits in PC-12 cells. AIMS Neurosci. 2021 Dec 23;9 (1) :12-23. |[6]Bermudez-Martin P, et al., The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021 Jul 8;9 (1) :157. |[7]Chang MC, et al., Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Atherosclerosis. 2011 Dec;219 (2) :559-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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