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FIP22

CAT: 0013-GTR19275118-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275118-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FIP22 is a potent and selective IRAK4 PROTAC degrader with a DC50 of 3.2 nM in HEK293T cells and 10.6 nM in THP-1 cells. It induces the ubiquitin-proteasome system through the formation of an IRAK4-FIP22-CRBN ternary complex (EC50= 12.63 nM), effectively inhibiting the NF-κB and MAPK signaling pathways mediated by IRAK4. FIP22 is applicable for researching atopic dermatitis.
CAS Number
3091132-73-6
Smiles
C (=O) (N1CCC2 (CCN (CC2) C=3C=C4C (=CC3) C (=O) N (C4=O) C5C (=O) NC (=O) CC5) CC1) [C@H]6CC[C@H] (NC (=O) C=7C (NC (C) C) =CC (=NC7) N8C=9C (C=C8) =CC (C#N) =CN9) CC6
Molecular Formula
C46H50N10O6
Molecular Weight
838.97
Storage Conditions
-20°C
Notes
For research use only.

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