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DdBIC

CAT: 0013-GTR19274699-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274699-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DdBIC is a pyroptosis inducer that associates with Nur77, facilitating its translocation to the mitochondria. This interaction activates the depletion of SDHA succinyl-CoA, disrupts hemeostasis, causes electron leakage, and stimulates mitochondrial ROS generation. Mitochondrial ROS, induced by DdBIC, oxidatively activates OMA1, leading to OPA1 cleavage and release into the cytoplasm, triggering the PERK-activated integrated stress response, ultimately activating granzyme B (granzyme B) to cleave GSDMC. DdBIC is applicable in melanoma research.
CAS Number
3085711-53-8
Smiles
O=C (OCCCCCCCCCCCC) C=1C=CC=2N=CNC2C1
Molecular Formula
C20H30N2O2
Molecular Weight
330.47
Storage Conditions
-20°C
Notes
For research use only.

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