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Legubicin

CAT: 0013-GTR19273044-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273044-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Legubicin (Doxorubicin-LNAA-Boc) is a conjugate of Doxorubicin linked with a peptide connector hydrolyzable by Legumain. Upon activation by Legumain, Legubicin releases leucine-Doxorubicin, potentially minimizing damage to normal tissues. It inhibits tumor cell growth and reduces DNA binding ability in cells lacking legumain expression. In mice with CT26 tumors, Legubicin completely suppresses tumor growth, making it useful for colon cancer (CRC) research.
CAS Number
606967-53-7
Smiles
O ([C@@H]1C2=C (C (O) =C3C (=C2O) C (=O) C=4C (C3=O) =CC=CC4OC) C[C@] (C (CO) =O) (O) C1) [C@H]5C[C@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC (OC (C) (C) C) =O) C) =O) C) =O) CC (N) =O) =O) CC (C) C) =O) [C@H] (O) [C@H] (C) O5
Molecular Formula
C48H64N6O18
Molecular Weight
1013.06
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-176806-01Legubicin

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