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Lipid 114

CAT: 0013-GTR19265547-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19265547-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1β can reduce IL-1β expression in macrophages. Additionally, these LNPs lower IL-1β expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure.
Field of Research
Metabolism Research
Storage Conditions
-20°C
Notes
For research use only.

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