Products for Research Use Only

TQ-3959

CAT: 0013-GTR19264968-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264968-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TQ-3959 is an orally active BTKPROTAC degrader, with a DC50 of 14.6 nM. It exhibits antiproliferative activity against both wild-type BTK and BTK C481S mutant cell lines. TQ-3959 demonstrates tumor growth inhibition in female NOD-SCID mice with TMD-8 xenografts. This compound is applicable in the study of B-cell malignancies, such as lymphoma.
CAS Number
2926610-43-5
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C (C=2C=3C (=CC (=CC3) N4CC (C4) N5CCC (CC5) C6=CC=C (NC7=NC (=CN=C7C (N) =O) N8C[C@@H] (CCC8) N9C (=O) N (C) CC9) C=C6) ON2) CCC (=O) N1
Molecular Formula
C40H47N11O5
Molecular Weight
761.87
Storage Conditions
-20°C
Notes
For research use only.