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MMRi6

CAT: 0013-GTR19264408-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264408-01Size:10 mg
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Description
MMRi6 is an inhibitor of the Mdm2-MdmX RING domain, capable of disrupting Mdm2-MdmX RING-RING interactions in vitro. It inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated polyubiquitination of p53 without affecting NEDD4-1 autoubiquitination. In wt-p53 Emu-myc lymphoma cells, MMRi6 induces p53 stabilization and accumulation, as well as PARP cleavage. It inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells, with IC50 values of approximately 0.5 μM and 3 μM, respectively. MMRi6 is applicable in leukemia/lymphoma research.
CAS Number
709009-15-4
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
ClC1=CC=CC (=C1) C (NC2=NC=CC=C2) C3=CC (Cl) =C4C=CC=NC4=C3O
Molecular Formula
C21H15Cl2N3O
Molecular Weight
396.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-Chloro-7-((3-chlorophenyl)(pyridin-2-ylamino)methyl)quinolin-8-ol
CAS Number709009-15-4
PubChem CID2960962
IUPAC Name5-chloro-7-[(3-chlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
Molecular FormulaC21H15Cl2N3O
Molecular Weight396.3
XLogP5.5
Topological Polar Surface Area58
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity482
SMILES
C1=CC=NC(=C1)NC(C2=CC(=CC=C2)Cl)C3=CC(=C4C=CC=NC4=C3O)Cl
InChI
InChI=1S/C21H15Cl2N3O/c22-14-6-3-5-13(11-14)19(26-18-8-1-2-9-24-18)16-12-17(23)15-7-4-10-25-20(15)21(16)27/h1-12,19,27H,(H,24,26)
InChIKey
QEMVHDDDWVNQAB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Chloro-7-((3-chlorophenyl)(pyridin-2-ylamino)methyl)quinolin-8-ol
CAS: 709009-15-4
CID: 2960962
Formula: C21H15Cl2N3O
MW: 396.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.3
XLogP35.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass395.0592175
Monoisotopic Mass395.0592175
Topological Polar Surface Area58 Ų
Heavy Atom Count27
Formal Charge0
Complexity482
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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