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DeFer-2

CAT: 0013-GTR19264393-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264393-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM) . It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
CAS Number
3058911-16-0
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
C ([C@@H] (NC (CCCNC (CCCCCCC/C=C\CCCCCCCC) =O) =O) [C@] (C) (C) C) (=O) N1[C@H] (C (NCC2=CC=C (C=C2) C=3SC=NC3C) =O) C[C@@H] (O) C1
Molecular Formula
C44H69N5O5S
Molecular Weight
780.11
Storage Conditions
-20°C
Notes
For research use only.

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