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LCZ960

CAT: 0013-GTR19264367-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264367-02Size:50 mg
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Description
LCZ960 is an orally active glucokinase (GK) activator that stimulates GK activity in liver cells in vitro and enhances glucose uptake in vivo by activating hepatic GK. It effectively lowers blood glucose levels in diet-induced obesity (DIO) in mice. LCZ960 maintains normal blood sugar and improves glucose tolerance in DIO mice and rats. Additionally, LCZ960 stimulates glycogen synthase flux and increases glycogen turnover in the liver of rats, inducing an increase in hepatic glycogen cycling. This compound is useful for research on obesity and type 2 diabetes induced by high-fat diets.
CAS Number
1067877-83-1
Field of Research
Metabolism Research
Smiles
N (C ([C@H] (CC1CCCC1) C2=CC=C (S (=O) (=O) N3CCN (C) CC3) C=C2) =O) C=4SC=5C (N4) =CC=C (N5) C=6C=CN=CC6
Molecular Formula
C30H34N6O3S2
Molecular Weight
590.76
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(2R)-3-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-(5-pyridin-4-yl-[1,3]thiazolo[5,4-b]pyridin-2-yl)propanamide
CAS Number1067877-83-1
PubChem CID24970350
IUPAC Name(2R)-3-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-(5-pyridin-4-yl-[1,3]thiazolo[5,4-b]pyridin-2-yl)propanamide
Molecular FormulaC30H34N6O3S2
Molecular Weight590.8
XLogP4.9
Topological Polar Surface Area145
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Heavy Atom Count41
Formal Charge0
Complexity967
SMILES
CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)[C@@H](CC3CCCC3)C(=O)NC4=NC5=C(S4)N=C(C=C5)C6=CC=NC=C6
InChI
InChI=1S/C30H34N6O3S2/c1-35-16-18-36(19-17-35)41(38,39)24-8-6-22(7-9-24)25(20-21-4-2-3-5-21)28(37)34-30-33-27-11-10-26(32-29(27)40-30)23-12-14-31-15-13-23/h6-15,21,25H,2-5,16-20H2,1H3,(H,33,34,37)/t25-/m1/s1
InChIKey
LAYAEBGGDTWXAZ-RUZDIDTESA-N
Chemical Structure
2D Structure
2D structure of (2R)-3-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-(5-pyridin-4-yl-[1,3]thiazolo[5,4-b]pyridin-2-yl)propanamide
CAS: 1067877-83-1
CID: 24970350
Formula: C30H34N6O3S2
MW: 590.8
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight590.8
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass590.21338131
Monoisotopic Mass590.21338131
Topological Polar Surface Area145 Ų
Heavy Atom Count41
Formal Charge0
Complexity967
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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