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Conophyllidine

CAT: 0013-GTR19264310-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264310-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 μM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.
CAS Number
152406-44-5
Field of Research
Epigenetics & Chromatin, Immunology & Inflammation
Smiles
C (C) [C@@]12[C@]3 ([C@@]4 (C (=C (C (OC) =O) C1) NC=5C4=CC (O) =C (OC) C5OC) CCN3[C@]6 ([C@@] ([C@H]2O) (OC=7C6=CC8=C (C7) NC=9[C@@]8%10[C@@]%11 ([C@] (CC) (CC9C (OC) =O) C=CCN%11CC%10) [H]) [H]) [H]) [H]
Molecular Formula
C44H50N4O9
Molecular Weight
778.89
Storage Conditions
-20°C
Notes
For research use only.

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