ARN25657

CAT: 0013-GTR19264076-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19264076-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ARN25657 is a dual regulator of D3R/GSK-3β. It demonstrates partial agonist activity at the D3 receptor (EC50 = 15.2 nM, Ki = 1.5 nM) alongside potent inhibitor activity against GSK-3β (IC50 = 19.3 nM) . ARN25657 shows excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. It inhibits P-gp-mediated efflux of acetoxymethyl calcein, enhancing in vitro ADME properties while maintaining balanced dual-target distribution. ARN25657 is applicable in the study of bipolar disorder and related neuropsychiatric conditions.

Field of Research

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Storage Conditions

-20°C

Notes

For research use only.

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T211728-01	ARN25657

ARN25657

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