Products for Research Use Only
RegisterLogin

LCL768

CAT: 0013-GTR19263885-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19263885-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LCL768 is a ceramide analogue that attenuates PARKIN succinylation, thereby promoting PARKIN activation and mitophagy. It induces the accumulation of CerS1-mediated endogenous C18-ceramide in mitochondria, facilitating mitophagy through DRP1 activation via C644 site nitrosylation. Additionally, LCL768 alters mitochondrial metabolism, depleting fumarate and inhibiting tumor growth. Furthermore, it ameliorates sensorimotor deficits in neurodegenerative diseases such as ALS.
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19172402-01LCL161
GTR19164100-01LCL161

Alternative Products

CatalogName
T211513-01LCL768

Popular Products