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Astringin

CAT: 0804-HY-N4093-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4093-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Astringin (trans-Astringin) is an orally active natural flavonoid compound. Astringin can inhibit the production of oxidative stress, inflammatory factors, etc. Astringin has multiple activities such as anti-oxidation, anti-inflammation, and anti-apoptosis. Astringin is also an inhibitor of ferroptosis. Astringin can be used in the research of diseases such as acute lung injury[1][2][3][4].
CAS Number
29884-49-9
Product Name Alternative
Trans-Astringin
UNSPSC
12352005
Target
Akt; Apoptosis; Ferroptosis; Interleukin Related; MyD88; NF-κB; PI3K; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/astringin.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=CC(/C=C/C2=CC(O)=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C2)=C1
Molecular Formula
C20H22O9
Molecular Weight
406.38
References & Citations
[1]Le TK, et al. Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one-step synthesis of astringin, a piceatannol glucoside, by P450 BM3. Enzyme Microb Technol. 2017 Feb;97:34-42.|[2]Wang L, et al. Astringin protects LPS-induced toxicity by suppressing oxidative stress and inflammation via suppression of PI3K/AKT/NF-κB pathway for pediatric acute lung injury. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396 (10) :2369-2377.|[3]Chen B, et al. Comparison of Ferroptosis-Inhibitory Mechanisms between Ferrostatin-1 and Dietary Stilbenes (Piceatannol and Astringin) . Molecules. 2021 Feb 19;26 (4) :1092.|[4]Hu H, et al. Pharmacotherapeutic role of astringin against chromium induced nephrotoxicity via modulating TLR4/MyD88, HMGB1/RAGE and NF-κB pathway: A biochemical and pharmacokinetic approach. J Trace Elem Med Biol. 2025 May 2;89:127666.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; TLR4

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