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USP7-IN-18

CAT: 0013-GTR19263712-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263712-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP7-IN-18 (Compound X21) serves as a novel USP7 inhibitor by directly suppressing enzyme activity and modulating downstream pathways, including the newly identified PCLAF target. At concentrations of 0.25-1 μM for 24 hours, it exhibits inhibitory effects. USP7-IN-18 effectively reduces proliferation in leukemia (RS4;11) and colon cancer (MC38/CT26.WT) cells at 0.01-100 μM over 72 hours. It demonstrates high selectivity for USP7 at 2.5 μM within 0.5 hours, surpassing eight other deubiquitinating enzymes. SPR analysis shows that at 1.95-2000 nM for 3 minutes, the compound binds the catalytic domain of USP7 with a KD value of 4.9 μM.
CAS Number
3052223-40-9
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry
Smiles
O=C1N (C (=O) C2C1C2 (C) C) CC=3SC=4C (=NC=CC4C5=CC (Cl) =C6C=CC=CC6=C5OC7CCNCC7) C3
Molecular Formula
C30H28ClN3O3S
Molecular Weight
546.08
Storage Conditions
-20°C
Notes
For research use only.

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