Products for Research Use Only

AY-4

CAT: 0013-GTR19263637-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263637-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AY-4 (Compound AY-4) is a potent PROTAC degrader targeting FTH1, with a dissociation constant (Kd) of 3.17 nM. It effectively increases intracellular ferrous (Fe2+) and ferric (Fe3+) ion levels. AY-4 is a potential anticancer candidate that regulates iron homeostasis through ferritin degradation, enhancing the efficacy of existing drugs. Additionally, AY-4 significantly reduces FTH1 levels in breast cancer cells.
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Storage Conditions
-20°C
Notes
For research use only.

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