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INCB126503

CAT: 0013-GTR19263557-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263557-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INCB126503 is an orally active and selective inhibitor of FGFR2/3, with IC50 values of 70 nM for FGFR1, 2.1 nM for FGFR2, 1.2 nM for FGFR3, 0.92 nM for FGFR3-V555L, 0.85 nM for FGFR3-V555M, and 64 nM for FGFR4. This compound inhibits FGFR signaling in vivo without causing hyperphosphatemia and demonstrates antitumor efficacy in xenograft models with FGFR3 genetic alterations.
CAS Number
2640089-88-7
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C) C=1C=C2C (C (=NN2) C=3C=CC (=NC3) N4C[C@]5 (N (CC4) C[C@H] (O) C5) [H]) =NC1C6=C (C) C (C) =CC=C6
Molecular Formula
C27H30N6O2
Molecular Weight
470.57
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-174154INCB126503

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