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OXPHOS-IN-2

CAT: 0013-GTR19263768-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263768-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OXPHOS-IN-2 is an orally active inhibitor of OXPHOS, demonstrating potent inhibitory effects in PC9 cells (IC50= 12.3 nM) and Bxpc-3 cells (IC50= 250 nM in glucose medium, IC50= 17.5 nM in galactose medium) . It modulates the NADH/NAD+ ratio and decreases ATP levels. OXPHOS-IN-2 induces apoptosis in tumor cells by activating reactive oxygen species (ROS) and downregulating Nrf2 levels. This compound is applicable for research in cancers such as non-small cell lung cancer and pancreatic cancer.
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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