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EGFR/CA-IX-IN-1

CAT: 0013-GTR19263337-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263337-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor of epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX), with IC50 values of 5.92 nM and 63 nM, respectively. This compound exhibits significant cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM. Additionally, EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, increases the BAX/Bcl-2 ratio, activates caspases, and causes cell cycle arrest at the G1 phase. It shows potential for breast cancer research.
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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