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ETN029

CAT: 0013-GTR19263039-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263039-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ETN029 is a ligand targeting DLL3. The 225Ac-labeled ETN029 exhibits dose-dependent cytotoxic effects on small cell lung cancer (SCLC), neuroendocrine prostate cancer (NEPC), and metastatic melanoma cells, and can induce H2AX phosphorylation. The 177Lu-labeled ETN029 has rapid tumor uptake, sustained retention, and a favorable tumor-to-renal distribution ratio. Therefore, ETN029 can be used for imaging and mechanism studies of tumors such as SCLC and NEPC.
CAS Number
3066864-32-9
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
C ([C@@H] (C (=O) N1[C@H] (C (N) =O) CCC1) NC (=O) [C@H]2NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CCCCNC (CN3CCN (CC (O) =O) CCN (CC (O) =O) CCN (CC (O) =O) CC3) =O) NC (=O) [C@H] (CC4=CC5=C (C=C4) C=CC=C5) NC (=O) [C@H] (CC (N) =O) NC (=O) [C@H] (CC6CCN (CC (O) =O) CC6) NC (=O) [C@@H] (NC ([C@@H] (N (C ([C@@H] (NC ([C@H] (CC=7C=8C (NC7) =CC=CC8) NC (C) =O) =O) [C@@H] (C) O) =O) C) CC (C) (C) C) =O) CSCSC2) C=9C=%10C (NC9) =CC=CC%10
Molecular Formula
C101H140N22O26S2
Molecular Weight
2142.48
Storage Conditions
-20°C
Notes
For research use only.

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T210498-01ETN029

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