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HL435

CAT: 0013-GTR19262953-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262953-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HL435 is a heterobifunctional molecule that degrades BRD4 by linking with JQ1, with DC50 values of 11.9 nM and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. It inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1, and A549 cells, arrests the cell cycle, and induces apoptosis. Additionally, HL435 exhibits antitumor activity in mouse models.
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Molecular Formula
C47H48BrClF3N7O7S
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
T210387-01HL435

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