Proquazone

CAT: 0804-HY-17491-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-17491-01Size:1 mg

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Description

Proquazone (RU 43-715) is a chemically distinctive non-steroidal anti-inflammatory agent (NSAID) and an inhibitor of calcium sensing receptor (CaSR) . unlike most other NSAIDs, Proquazone does not have a free acid group in its structure. Proquazone may inhibit or arrest progression of bone erosions. Proquazone is an orally active anti-inflammatory, analgesic and anti-pyretic agent[1].

CAS Number

22760-18-5

Product Name Alternative

RU 43-715; Sandoz-43-715

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/proquazone.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C(C)C)C2=C(C=CC(C)=C2)C(C3=CC=CC=C3)=N1

Molecular Formula

C18H18N2O

Molecular Weight

278.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Proquazone

Proquazone is a member of pyrimidines.

CAS Number	22760-18-5
PubChem CID	31508
IUPAC Name	7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
Molecular Formula	C18H18N2O
Molecular Weight	278.3
XLogP	3
Topological Polar Surface Area	32.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Heavy Atom Count	21
Formal Charge	0
Complexity	423

SMILES

CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3

InChI

InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

InChIKey

JTIGKVIOEQASGT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 22760-18-5

CID: 31508

Formula: C18H18N2O

MW: 278.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	278.3
XLogP3	3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	278.141913202
Monoisotopic Mass	278.141913202
Topological Polar Surface Area	32.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	423
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS5764868	Proquazone
463121-01	Proquazone discontinued

Proquazone

Chemical Information

Alternative Products

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