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KDM5B-IN-4

CAT: 0013-GTR19262169-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262169-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KDM5B-IN-4 (compound 11ad) is a novel inhibitor of lysine demethylase 5B (KDM5B), with an IC50 of 0.025 μM for KDM5B. It increases the levels of the substrate H3K4me1/2/3 in PC-3 cells by inhibiting KDM5B. Furthermore, KDM5B-IN-4 induces G2/M phase arrest in PC-3 cells and downregulates proteins in the PI3K/AKT signaling pathway. Additionally, KDM5B-IN-4 reduces tumor volume in mice with minimal organ toxicity.
Field of Research
Epigenetics & Chromatin, Metabolism Research
Molecular Formula
C30H30N6O
Storage Conditions
-20°C
Notes
For research use only.

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