FBXW7

CAT: 0579-X2337BSize: 50 µgDry Ice: NoHazardous: No
CAT#:0579-X2337BSize:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Synonyms
F-box and WD-40 Domain Protein 7, FBXW7, CDC4
UniProt
Q969H0
Host
Rabbit
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Assay Principle
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P , X2336P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Strohmaier, H., et al. 'Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.; Nature 413:316-322(2001). 2. Moberg, K.H., et al. 'Archipelago regulates cyclin E levels in Drosophila and is mutated in Human cancer cell lines.; Nature 413:311-316(2001).
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

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