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Fluphenazine hydrochloride

CAT: 0013-GTR19260878-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19260878-01Size:10 mg
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Description
Fluphenazine hydrochloride is an effective, orally active phenothiazine class dopamine receptor (dopamine receptor) antagonist. It blocks voltage-gated sodium ion channels (sodium channels) in neurons. The compound primarily exerts its effects by antagonizing postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways. It counteracts stereotypy induced by methylphenidate in mice and suppresses climbing behavior. Fluphenazine hydrochloride is used in studying psychoses and diabetic-related painful peripheral neuropathy, with potential to inhibit SARS-CoV-2.
CAS Number
1254-47-3
Field of Research
Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery
Smiles
Cl.FC (F) (F) C1=CC=C2SC=3C=CC=CC3N (C2=C1) CCCN4CCN (CCO) CC4
Molecular Formula
C22H27ClF3N3OS
Molecular Weight
473.98
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Prolixin

See also: Fluphenazine Decanoate (annotation moved to); Fluphenazine Hydrochloride (annotation moved to); Flumezin (annotation moved to) ... View More ...

CAS Number1254-47-3
PubChem CID6602611
IUPAC Name2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride
Molecular FormulaC22H27ClF3N3OS
Molecular Weight474.0
Topological Polar Surface Area55.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity544
SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl
InChI
InChI=1S/C22H26F3N3OS.ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;/h1-2,4-7,16,29H,3,8-15H2;1H
InChIKey
CUXQPMGPJPHNFO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Prolixin
CAS: 1254-47-3
CID: 6602611
Formula: C22H27ClF3N3OS
MW: 474.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight474.0
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass473.1515458
Monoisotopic Mass473.1515458
Topological Polar Surface Area55.3 Ų
Heavy Atom Count31
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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