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TGFβRII-IN-3

CAT: 0013-GTR19262399-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262399-01Size:50 mg
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Description
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.
CAS Number
2351149-20-5
Field of Research
Stem Cell & Developmental Biology
Smiles
O=C (C=1C=2C (=O) CC (C) (C) CC2NC1C) N (C) CC3=CC=CC (=C3) C4=CC=C (C=C4) C (F) (F) F
Molecular Formula
C27H27F3N2O2
Molecular Weight
468.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N,2,6,6-tetramethyl-4-oxo-N-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-5,7-dihydro-1H-indole-3-carboxamide
CAS Number2351149-20-5
PubChem CID171357522
IUPAC NameN,2,6,6-tetramethyl-4-oxo-N-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-5,7-dihydro-1H-indole-3-carboxamide
Molecular FormulaC27H27F3N2O2
Molecular Weight468.5
XLogP5.5
Topological Polar Surface Area53.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count34
Formal Charge0
Complexity759
SMILES
CC1=C(C2=C(N1)CC(CC2=O)(C)C)C(=O)N(C)CC3=CC(=CC=C3)C4=CC=C(C=C4)C(F)(F)F
InChI
InChI=1S/C27H27F3N2O2/c1-16-23(24-21(31-16)13-26(2,3)14-22(24)33)25(34)32(4)15-17-6-5-7-19(12-17)18-8-10-20(11-9-18)27(28,29)30/h5-12,31H,13-15H2,1-4H3
InChIKey
LKBNJIFCVDFAFI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N,2,6,6-tetramethyl-4-oxo-N-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-5,7-dihydro-1H-indole-3-carboxamide
CAS: 2351149-20-5
CID: 171357522
Formula: C27H27F3N2O2
MW: 468.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.5
XLogP35.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass468.20246259
Monoisotopic Mass468.20246259
Topological Polar Surface Area53.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity759
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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