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200Oi10

CAT: 0013-GTR19259990-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259990-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
​​200Oi10​​ is an ionizable lipidoid used in lipid nanoparticles (LNPs) for RNA delivery. Structurally, it features ester-conjugated cleavable lipid tails, enhancing biodegradability and reducing toxicity compared to non-cleavable analogs. Preclinical studies show that 200Oi10-based LNPs primarily accumulate in the liver (97.7%) after intravenous administration. However, intraperitoneal injection redirects biodistribution, achieving 46.4% pancreatic uptake, which can be further amplified by incorporating cationic lipids like DOTAP. This unique tropism enables pancreas-targeted mRNA delivery. 200Oi10's ester linkages promote rapid clearance, improving biocompatibility while maintaining siRNA/mRNA delivery efficiency. Its design exemplifies the use of degradable lipidoids to balance organ specificity, efficacy, and safety in RNA therapeutics.
Purity
0.98
Smiles
CC (C) CCCCCCCOC (=O) CCN (CCC (=O) OCCCCCCCC (C) C) CCN (CCC (=O) OCCCCCCCC (C) C) CCN1CCN (CCN (CCC (=O) OCCCCCCCC (C) C) CCC (=O) OCCCCCCCC (C) C) CC1
Molecular Formula
C75H145O10N5
Molecular Weight
1277.01
Notes
For research use only.

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