AM432 sodium

CAT: 0013-GTR19259524Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19259524Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AM 432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.AM-432 shows no cross-reactivity against the TP or IP receptors, COX-1 or COX-2 and minimal activity at DP1 receptor. AM432 shows excellent potency in a human whole blood eosinophil shape change assay.AM432 exhibits efficacy in both a murine model of allergic rhinitis and a cigarette smoke induced inflammatory model of COPD.

CAS Number

1263409-34-2

Purity

>98%

Smiles

[NaH].C (C1C=C (C2=CN=C (OCC) C=C2) C=CC=1C1C=C (CC (=O) O) C=CC=1OC) N (CC) C (C1CC1) =O

Molecular Formula

C29H33N2NAO5

Molecular Weight

512.57

Notes

For research use only.

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AM432 sodium

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