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YJ1206

CAT: 0013-GTR19259461Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259461Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YJ1206 is an orally bioavailable PROTAC compound that selectively degrades CDK12 and CDK13, demonstrating potent activity (IC50 = 12.55 nM) in VCaP cells. It induces DNA damage, triggers apoptosis, and drives tumor regression in treatment-resistant prostate cancer PDX models, highlighting its therapeutic potential.
CAS Number
3053716-98-3
Purity
>98%
Smiles
O=C (NCC1=CC=CC=C1) N (C2=CN=C (N3CCN (C4CCN (C5=C (F) C=C (C (N (C6CCC (NC6=O) =O) C7=O) =O) C7=C5) CC4) CC3) C=C2) [C@H] (CC8) CC[C@@H]8NC9=NC=C%10C (C=CC=C%10) =N9
Molecular Formula
C49H52FN11O5
Molecular Weight
894.01
Notes
For research use only.

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BUP21023-01YJ1206
A24281-100YJ1206 100mg
A24281-50YJ1206 50mg
A24281-5YJ1206 5mg
A24281-10YJ1206 10mg

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