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BLINK11

CAT: 0013-GTR19258082-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258082-02Size:10 mg
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Description
BLINK11 is a blood-brain barrier-permeable inhibitor of Cdk5. It reduces the activity of CDK5 by targeting CDK5/p35 (IC50 = 17.09 nM) and CDK5/p25 (IC50 = 14.69 nM) complexes. BLINK11 exhibits antidiabetic and neuroprotective properties, lowers blood glucose levels in type 2 diabetes (T2D) mice, enhances cognitive function, and reduces neurodegenerative lesions.
CAS Number
712339-45-2
Field of Research
Cell Biology
Smiles
O=C (NC1=C (Cl) C (Cl) =CC=C1) C2=CC=CC=C2OCC (NC3=CC (Cl) =C (N4CCOCC4) C=C3) =O
Molecular Formula
C25H22Cl3N3O4
Molecular Weight
534.82
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(2-{[3-chloro-4-(4-morpholinyl)phenyl]amino}-2-oxoethoxy)-N-(2,3-dichlorophenyl)benzamide
CAS Number712339-45-2
PubChem CID1301563
IUPAC Name2-[2-(3-chloro-4-morpholin-4-ylanilino)-2-oxoethoxy]-N-(2,3-dichlorophenyl)benzamide
Molecular FormulaC25H22Cl3N3O4
Molecular Weight534.8
XLogP5.3
Topological Polar Surface Area79.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity711
SMILES
C1COCCN1C2=C(C=C(C=C2)NC(=O)COC3=CC=CC=C3C(=O)NC4=C(C(=CC=C4)Cl)Cl)Cl
InChI
InChI=1S/C25H22Cl3N3O4/c26-18-5-3-6-20(24(18)28)30-25(33)17-4-1-2-7-22(17)35-15-23(32)29-16-8-9-21(19(27)14-16)31-10-12-34-13-11-31/h1-9,14H,10-13,15H2,(H,29,32)(H,30,33)
InChIKey
BABYGKHHXCFNDV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-{[3-chloro-4-(4-morpholinyl)phenyl]amino}-2-oxoethoxy)-N-(2,3-dichlorophenyl)benzamide
CAS: 712339-45-2
CID: 1301563
Formula: C25H22Cl3N3O4
MW: 534.8
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight534.8
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass533.067589
Monoisotopic Mass533.067589
Topological Polar Surface Area79.9 Ų
Heavy Atom Count35
Formal Charge0
Complexity711
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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