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EG31

CAT: 0013-GTR19257907-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257907-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.
CAS Number
360760-58-3
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1OC (=NC2=CC=C (Br) C=C12) C=3C=C (C=C (C3) N4C (=O) C=5C=CC=CC5C4=O) C6=NC7=CC=C (Br) C=C7C (=O) O6
Molecular Formula
C30H13Br2N3O6
Molecular Weight
671.25
Storage Conditions
-20°C
Notes
For research use only.

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