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PI3K-IN-59

CAT: 0013-GTR19257659-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257659-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3K-IN-59 (Compound 3d) is a PI3K inhibitor with an IC50 value of 17.44 μM. It demonstrates significant antiproliferative activity, showing potent inhibition against breast cancer 4T1 cells (IC50: 3.70 μM), colon cancer CT26 cells (IC50: 1.98 μM), and human breast cancer cells (IC50: 19.72 μM) . The compound operates through a dual antitumor mechanism by inhibiting PI3Kα enzymatic activity and inducing hydroxyl radical (•OH) generation via the Fenton reaction. PI3K-IN-59 shows promising efficacy against 4T1 tumors, making it suitable for synergistic targeting studies in breast and colon cancer.
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Molecular Formula
C25H32FeN6O4
Storage Conditions
-20°C
Notes
For research use only.

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