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Vancomycin prodrug

CAT: 0013-GTR19258457-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258457-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vancomycin prodrug (compound 13c) is a prodrug of Vancomycin. It exhibits antibacterial activity against Staphylococcus aureus (S. aureus) 330041, methicillin-resistant Staphylococcus aureus (MRSA) USA 300, and MRSA 3390, with minimum inhibitory concentrations (MICs) of 0.78 μM, 0.78 μM, and 1.56 μM, respectively. This prodrug can rapidly bind to the Cys-34 residue in plasma. It demonstrates therapeutic efficacy in mice infected with MRSA USA300, comparable to Vancomycin. As an albumin-binding, acid-sensitive prodrug, Vancomycin prodrug maintains Vancomycin's effectiveness against gram-positive bacterial infections while significantly reducing nephrotoxicity.
Field of Research
Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery
Molecular Formula
C85H95Cl2N11O29
Storage Conditions
-20°C
Notes
For research use only.

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