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SPA-10091-HCl

CAT: 0013-GTR19257824-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257824-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPA-10091-HCl is a DOT1L degrader that selectively degrades the DOT1L protein via the nuclear ubiquitin-proteasome pathway, thereby inhibiting H3K79 methylation in CRPC cells. It also inhibits DOT1L enzymatic activity (IC50 = 0.87 μM), induces apoptosis, and significantly suppresses tumor growth in vivo.
Storage Conditions
-20°C
Notes
For research use only.

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