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Givinostat

CAT: 0013-GTR19257528-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257528-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Givinostat (ITF-2357) is an orally bioavailable, pan-HDAC inhibitor that blocks STAT5 phosphorylation, demonstrating antitumor effects in crlf2-rearranged BCP-ALL models. Its anti-inflammatory properties, including suppression of TNF-α and IL-1β, and promotion of β-cell survival support research in leukemia, diabetes, and arthritis, as evidenced by in vitro and in vivo studies.
CAS Number
497833-27-9
Product Name Alternative
ITF-2357, ITF2357, Givinostat
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.56% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:4 mg/mL (9.49 mM) ; DMSO:160 mg/mL (379.6 mM)
Smiles
CCN (CC) Cc1ccc2cc (COC (=O) Nc3ccc (cc3) C (=O) NO) ccc2c1
Molecular Formula
C24H27N3O4
Molecular Weight
421.5
Storage Conditions
-20°C
Notes
For research use only.

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