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N6- (2-Hydroxyethyl) adenosine

CAT: 0804-HY-W006957-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W006957-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N6- (2-Hydroxyethyl) adenosine is a purine nucleoside analog. N6- (2-Hydroxyethyl) adenosine inhibits NF-κB/Smad signaling pathway, exhibits anti-hyperglycemia, antioxidant, antitumor and anti-inflammatory and insecticidal activities. N6- (2-Hydroxyethyl) adenosine is orally active[1][2][3][4][5].
CAS Number
4338-48-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Insecticide; Mitochondrial Metabolism; NF-κB; Nucleoside Antimetabolite/Analog; Reactive Oxygen Species (ROS) ; SOD; TGF-beta/Smad
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/n6-2-hydroxyethyl-adenosine.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCCNC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
Molecular Formula
C12H17N5O5
Molecular Weight
311.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26 (6) :1490-1500.|[2]Wang X, et al., N6 - (2-hydroxyethyl) -adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation. J Food Biochem. 2019 Feb;43 (2) :e12727.|[3]Zheng R, et al., N6- (2-Hydroxyethyl) Adenosine From Cordyceps cicadae Ameliorates Renal Interstitial Fibrosis and Prevents Inflammation via TGF-β1/Smad and NF-κB Signaling Pathway. Front Physiol. 2018 Sep 4;9:1229.|[4]Xie H, et al., N6- (2-hydroxyethyl) -Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo. Int J Mol Sci. 2020 Aug 13;21 (16) :5815.|[5]Fang M, et al., N6- (2-Hydroxyethyl) -Adenosine Exhibits Insecticidal Activity against Plutella xylostella via Adenosine Receptors. PLoS One. 2016 Sep 26;11 (9) :e0162859.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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