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Hydroxyfasudil

CAT: 0804-HY-13911-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13911-01Size:5 mg
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Description
Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
CAS Number
[105628-72-6]
Product Name Alternative
HA-1100
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Hydroxyfasudil.html
Purity
98.78
Solubility
DMSO : 7 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O
Molecular Formula
C14H17N3O3S
Molecular Weight
307.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36 (10) :2251-7. Epub 2005 Sep 1.|[2]Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16 (10) :842-7.|[3]Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66 (4) :325-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ROCK1; ROCK2

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