Propylthiouracil

CAT: 0804-HY-B0346-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0346-01Size:100 mg
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Description
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research[1].
CAS Number
[51-52-5]
Product Name Alternative
6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU
UNSPSC
12352005
Hazard Statement
H302, H351
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Propylthiouracil.html
Purity
99.88
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(C=C(CCC)N1)NC1=S
Molecular Formula
C7H10N2OS
Molecular Weight
170.23
Precautions
H302, H351
References & Citations
[1]Lamis Chamas, et al. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Int J Mol Sci. 2022 Oct 8;23 (19) :11938.|[2]Utsana Puapermpoonsiri, et al. Synergistic effect of phospholipid-based liposomes and propylthiouracil on U-937 cell growth. J Liposome Res. 2005;15 (3-4) :215-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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