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2,6-Dimethylquinoline

CAT: 0804-HY-W010195-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010195-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM[1][2][3].
CAS Number
877-43-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-6-dimethylquinoline.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC2=C(C=C1)N=C(C)C=C2
Molecular Formula
C11H11N
Molecular Weight
157.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Laura E Korhonen, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3808-15.|[2]L E Korhonen, et al. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol. 2007 Apr;150 (7) :932-42.|[3]Cun Zhang, et al. Studies on chemical constituents from roots of Peucedanum praeruptorum II. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31 (16) :1333-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP1; CYP2

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