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HSN748

CAT: 0013-GTR19250271-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250271-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSN748 is a ponatinib analog and multi-kinase inhibitor targeting FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. It demonstrates efficacy in suppressing the proliferation of both chronic and acute myeloid leukemia cell lines in vitro, supporting its use as a research tool in leukemia studies.
CAS Number
2409925-53-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C (NC1=CC=C (C (=C1) C (F) (F) F) CN2CCN (C) CC2) C=3C=NC=C (C#CC4=CN=C5C=CC=NN45) C3
Molecular Formula
C27H24F3N7O
Molecular Weight
519.521
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
CAS Number2409925-53-5
PubChem CID146476029
IUPAC Name5-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
Molecular FormulaC27H24F3N7O
Molecular Weight519.5
XLogP2.7
Topological Polar Surface Area78.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity881
SMILES
CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CN=CC(=C3)C#CC4=CN=C5N4N=CC=C5)C(F)(F)F
InChI
InChI=1S/C27H24F3N7O/c1-35-9-11-36(12-10-35)18-20-5-6-22(14-24(20)27(28,29)30)34-26(38)21-13-19(15-31-16-21)4-7-23-17-32-25-3-2-8-33-37(23)25/h2-3,5-6,8,13-17H,9-12,18H2,1H3,(H,34,38)
InChIKey
VGYXBHLKVLHPJH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
CAS: 2409925-53-5
CID: 146476029
Formula: C27H24F3N7O
MW: 519.5
Interactive 3D Structure
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Computed Properties
PropertyValue
Molecular Weight519.5
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass519.19944290
Monoisotopic Mass519.19944290
Topological Polar Surface Area78.7 Ų
Heavy Atom Count38
Formal Charge0
Complexity881
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-171146HSN748

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