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CRBN ligand-76

CAT: 0013-GTR19249579-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249579-01Size:50 mg
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Description
CRBN ligand-76 is a cereblon (CRBN) E3 ligase-binding molecule designed for constructing PROTAC degraders. It enables targeted protein degradation in both cellular and biochemical assays, supporting research in oncology and chemical biology.
CAS Number
3065251-82-0
Field of Research
Cancer Biology, Pharmacology & Drug Discovery
Smiles
O=C1NC (=O) C (C=2C=C (F) C (Br) =CC2F) CC1
Molecular Formula
C11H8BrF2NO2
Molecular Weight
304.088
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(4-Bromo-2,5-difluorophenyl)piperidine-2,6-dione
CAS Number3065251-82-0
PubChem CID176455454
IUPAC Name3-(4-bromo-2,5-difluorophenyl)piperidine-2,6-dione
Molecular FormulaC11H8BrF2NO2
Molecular Weight304.09
XLogP1.9
Topological Polar Surface Area46.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity339
SMILES
C1CC(=O)NC(=O)C1C2=CC(=C(C=C2F)Br)F
InChI
InChI=1S/C11H8BrF2NO2/c12-7-4-8(13)6(3-9(7)14)5-1-2-10(16)15-11(5)17/h3-5H,1-2H2,(H,15,16,17)
InChIKey
VKVPSDARJCGSNZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Bromo-2,5-difluorophenyl)piperidine-2,6-dione
CAS: 3065251-82-0
CID: 176455454
Formula: C11H8BrF2NO2
MW: 304.09
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.09
XLogP31.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass302.97065
Monoisotopic Mass302.97065
Topological Polar Surface Area46.2 Ų
Heavy Atom Count17
Formal Charge0
Complexity339
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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