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MSC1094308

CAT: 0804-HY-123872-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123872-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1]. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer[1].
CAS Number
2219320-08-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/msc1094308.html
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1
Molecular Formula
C29H29F3N2
Molecular Weight
462.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Pöhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57 (6) :1576-1580.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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