Langerin / CD207 Recombinant Rabbit Monoclonal Antibody [PSH04-60]

• Description:

  Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. It was discovered by scientists Sem Saeland and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in lymph nodes. Langerin has similar function and structure as a DCs surface protein DC-SIGN (CD209). Both receptors bind similar antigens via the CRD, for instance Mycobacterium tuberculosis and HIV-1. However, whereas HIV-1 binding to langerin leads to the elimination of the virus, HIV-1 binding to DC-SIGN leads to infection of the cell.

• Product Name Alternative:

  C type lectin domain family 4 member K antibody C-type lectin domain family 4 member K antibody CD 207 antibody CD207 antibody CD207 antigen antibody CD207 antigen, langerin antibody CD207 molecule antibody CLC4K_HUMAN antibody CLEC 4K antibody CLEC4K antibody Langerhans cell specific c type lectin antibody Langerin antibody RGD1565913 antibody

• Abbreviation:

  CD207, CLEC4K

• Swiss Prot:

  Q9UJ71 Human

• Cellular Locus:

  Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within human Langerin aa 1-43 / 328.

• Isotype:

  IgG

• Clone:

  PSH04-60

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P, IF-Cell, IF-Tissue

• Positive Control:

  Human lymph nodes tissue, human skin tissue, human tonsil tissue, 293T cells transfected with CD207/Langerin.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000 ;IHC-P: 1:4,000 ;IF-Cell: 1:2,500 ;IF-Tissue: 1:200-1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 37 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3