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AU-15330

CAT: 0013-GTR19244005-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19244005-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity.
CAS Number
2380274-50-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 140 mg/mL (185.20 mM; Ultrasonic)
Smiles
C[C@H] (NC (=O) [C@@H]1C[C@@H] (O) CN1C (=O) [C@@H] (NC (=O) CN1CCN (CC1) c1cc (nnc1N) -c1ccccc1O) C (C) (C) C) c1ccc (cc1) -c1scnc1C
Molecular Formula
C39H49N9O5S
Molecular Weight
755.93
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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