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Lersivirine

CAT: 0804-HY-14267-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14267-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC50=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains[1].
CAS Number
473921-12-9
Product Name Alternative
UK-453061
UNSPSC
12352005
Hazard Statement
H302
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Lersivirine.html
Concentration
10mM
Purity
98.38
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCC1=NN(CCO)C(CC)=C1OC2=CC(C#N)=CC(C#N)=C2
Molecular Formula
C17H18N4O2
Molecular Weight
310.35
Precautions
H302
References & Citations
[1]Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19 (20) :5857-60.|[2]Gregg D Cappon, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95 (3) :225-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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