Palmitic acid

Palmitic acid

• CAS Number: 57-10-3
• UNSPSC Description: Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model[1][2].
• Target Antigen: Endogenous Metabolite; HSP
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Metabolic Disease; Neurological Disease; Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Palmitic_acid.html
• Purity: 99.76
• Solubility: DMSO : 100 mg/mL (ultrasonic)|Ethanol : 12.82 mg/mL (ultrasonic)
• Smiles: CCCCCCCCCCCCCCCC(O)=O
• Molecular Weight: 256.42
• References & Citations: [1]Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.|[2]Wen-Jin Ding, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708.|[3]Liaqat H, et al. Antioxidant Effect of Wheat Germ Extracts and Their Antilipidemic Effect in Palmitic Acid-Induced Steatosis in HepG2 and 3T3-L1 Cells. Foods. 2021 May 12;10(5):1061.|[4]Jiang H, et al. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis. 2010 May;210(1):71-7.|[5]Ding WJ, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708. |[6]Urso CJ, et al. Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids. Int J Mol Sci. 2021 Aug 23;22(16):9093. |[7]Wu D, et al. Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med. 2014 Dec;34(6):1706-12.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: No Development Reported