Palmitic acid

CAT: 0804-HY-N0830-01Size: 500 mgDry Ice: NoHazardous: No

CAT#:0804-HY-N0830-01Size:500 mg

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Description

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model[1][2].

CAS Number

[57-10-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; HSP

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Palmitic_acid.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 12.82 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCC(O)=O

Molecular Formula

C16H32O2

Molecular Weight

256.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22 (5) :2587-90.|[2]Wen-Jin Ding, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22 (3) :1702-1708.|[3]Liaqat H, et al. Antioxidant Effect of Wheat Germ Extracts and Their Antilipidemic Effect in Palmitic Acid-Induced Steatosis in HepG2 and 3T3-L1 Cells. Foods. 2021 May 12;10 (5) :1061.|[4]Jiang H, et al. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis. 2010 May;210 (1) :71-7.|[5]Ding WJ, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22 (3) :1702-1708. |[6]Urso CJ, et al. Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids. Int J Mol Sci. 2021 Aug 23;22 (16) :9093. |[7]Wu D, et al. Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med. 2014 Dec;34 (6) :1706-12. |[8]Jeong Yeon Kim, et al. Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways. Sci Rep. 2017 Jun 28;7 (1) :4335. |[9]Yanzhuo Yang, et al. Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia. PLoS One. 2023 Apr 20;18 (4) :e0281189.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

HSP70; Human Endogenous Metabolite; Microbial Metabolite

Citation 01

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