Products for Research Use Only
RegisterLogin

S3226

CAT: 0013-GTR19249320-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19249320-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
S3226 is a potent and selective NHE3 inhibitor with an IC50 of 0.2 μM in transfected rat fibroblasts. It demonstrates protective efficacy in rodent models of ischemic acute kidney injury, supporting its use in research on renal physiology and pathophysiological mechanisms.
CAS Number
215183-03-2
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C (C (C) =CC1=CC=C (C) C=C1C=C (C) C (NC (N) =N) =O) NC (N) =N.Cl.Cl
Molecular Formula
C17H24Cl2N6O2
Molecular Weight
415.317
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride

inhibitor of Na+/H+ exchanger subtype 3; structure in first source

CAS Number215183-03-2
PubChem CID137313644
IUPAC Name(E)-N-(diaminomethylidene)-3-[2-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-4-methylphenyl]-2-methylprop-2-enamide;dihydrochloride
Molecular FormulaC17H24Cl2N6O2
Molecular Weight415.3
Topological Polar Surface Area163
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity640
SMILES
CC1=CC(=C(C=C1)/C=C(\C)/C(=O)N=C(N)N)/C=C(\C)/C(=O)N=C(N)N.Cl.Cl
InChI
InChI=1S/C17H22N6O2.2ClH/c1-9-4-5-12(7-10(2)14(24)22-16(18)19)13(6-9)8-11(3)15(25)23-17(20)21;;/h4-8H,1-3H3,(H4,18,19,22,24)(H4,20,21,23,25);2*1H/b10-7+,11-8+;;
InChIKey
KFFCDWFEJMZQKK-VHZUSOFISA-N
Chemical Structure
2D Structure
2D structure of 3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride
CAS: 215183-03-2
CID: 137313644
Formula: C17H24Cl2N6O2
MW: 415.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.3
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass414.1337794
Monoisotopic Mass414.1337794
Topological Polar Surface Area163 Ų
Heavy Atom Count27
Formal Charge0
Complexity640
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19189873-01S32826
GTR19200884-01S32826 disodium
GTR18964710ATF2 Antibody (S322) Blocking peptide
GTR18905056-01NFAT1 (phospho-S326) Blocking Peptide
GTR18273342HSF1 (Phospho-S326) Conjugated Antibody
GTR18969513ATF2 (Phospho-S322) Antibody Blocking peptide
GTR18112733-01NFAT1 (Phospho-S326) Rabbit Polyclonal Antibody
GTR18068811-01HSF1 (Phospho-S326) Rabbit mAb Antibody
GTR18969367NFATC2 (Phospho-S326) Antibody Blocking peptide
GTR18030442-01Phospho PLK1 (S326) Rabbit Polyclonal Antibody

Alternative Products

CatalogName
HY-156696-01S3226

Popular Products