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CTIBD

CAT: 0013-GTR19240115Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240115Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CTIBD is a novel potent activator of the BKCa channel with EC50 of 3.9 uM.CTIBD showed significantly higher potency compared with three other known BKCa activators: NS 1619, NS 11021, and rottlerin.CTIBD induced a reversible potentiation of macroscopic outward currents of the BKCa channel, CTIBD activates both rSlo/rβ1 and rSlo/rβ4 coexpressed channels mainly by decreasing the closing rate of the channel.CTIBD concentration-dependently reduced ACh-induced contractions in isolated rat urinary bladder strips. CTIBD effectively restored frequent voiding contraction and lowered voiding volume without affecting other bladder function parameters in acetic acid-induced overactive bladder (OAB) model (i.p. 20 mg/kg) .
CAS Number
879592-33-3
Purity
0.98
Molecular Formula
C16H9ClF3NO3
Molecular Weight
355.697
Notes
For research use only.

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